• Healthy Non-Smoking Females
• Age:  18-45
• BMI:  18 to 32 kg/m2
• Adequate kidney function (GFR): greater than 90 mL/min

Washout from previous study: Participants must not have been in any other study or received an investigational drug within 30 days prior to study dosing for this study.

Acceptable Birth Control for Females (if Childbearing): Child bearing Females must use a highly effective contraceptive method during the study beginning at the screening visit until final follow up, after the last dose of investigational drug.

Acceptable methods of birth control for use in this study are:

• Non-hormonal IUD
• Bilateral tubal occlusion (documents required)
• Vasectomized partner (documents required)
• Sexual Abstinence when in line with the preferred and usual lifestyle

Females in the following categories are considered non-childbearing:

• Documented hysterectomy (removal of uterus), bilateral salpingectomy (removal of both Fallopian tubes) or bilateral oophorectomy (removal of both ovaries)
• Postmenopausal when younger than 54 years of age with amenorrhea of at least 12 months if FHS level is in the postmenopausal range and not using hormonal contraception or hormone replacement therapy.

Unacceptable Birth Control Methods include Hormonal Contraception, periodic abstinence, withdrawal, spermicides only and lactational amenorrhea method. A female condom and a male condom should not be used together.

Females of childbearing potential must also refrain from egg donation and in vitro fertilization during treatment and until final follow up, after the last dose of investigational drug.